That was the first example that came to mind when I made that post. It made sense so I typed it.While I agree, you can't really use anime-based reasoning. Brock left his entire family to watch the Gym, Misty with her sisters. All of them are pure anime with no game-related ties.
Also, the new videos confirm that the purple haired girl from the anime is in the game and that the lil' mole evolves into the armored mole.