While I'd be the first to admit he wouldn't really be a justifiable pick within the average 20-or-so character fighter roster, or even a slightly bigger 30-to-40 character fighter roster, it would be great if Itchy was in a 50-or-so+ character Disney platform fighter if only to see him fight Mickey. I don't think he'd be that hard to censor either, remove the gore and even then Itchy is very distinguishable from a Jerry or Wile E. in personality and tools of the trade.
However, if the Disney fighter only used more mature acquired IPs or was focused on all the Fox sitcoms, I feel Itchy would be a must and a higher priority for Simpsons rep than even Lisa and Marge. Should go without saying in the case of a solely-Simpsons fighter, in that case he'd be as obvious to include as Link or Samus in Smash.