Real life obviously isn't even divided into frames, but the rate at which a human eye can percieve the world is much higher than 60fps, iirc. Also, doing something frame perfect isn't all that hard. It's doing it consistently that's the problem.
I think some people are confusing "frame perfect timing" with "frame perfect reaction time." The former means being able to time things precisely on the correct frame, whereas the latter means being able to react to things in one frame. A lot of people have frame perfect timing for a lot of things. Perfect wavedashes require frame perfect timing and many people can do those consistently. Infinite shines require frame perfect timing and many people can do those consistently (at least, for a few seconds). But absolutely no one can react with frame perfect timing. Not even close. The problem with Fox's dair pillar is that the timing for the L-cancel and the shine varies depending on how many of the dairs hit the shield. So the timing is variable, and when I said no one could do frame perfect pillars I meant it's because you would have to react to how many hits of the dair connect on the shield, which brings us into "frame perfect reaction time" which no one is even close to. Still, one might think with practice you could connect a consistent number of the dair hits on the shield, but this is impossible, because it depends on the shield size, which depends on the character as well as whether the shield is a light shield, full shield, or somewhere in between.
Still, some people can probably pillar shields fairly consistently, but the number of dair=> shines needed to break a shield is retardedly high because of the tiny shield decay compared to say, Falco's pillar. Which is why Fox's pillar is totally pointless. Especially since your enemy can just buffer a roll or a spot dodge while you're trying to do eight frame perfect dair shines on his shield.