Megamind and Despicable Me are probably the "twin movies" with the most drastic a quality gap - not that Despicable Me is a bad movie (it's a fun slapstick comedy, better than a lot of its contemporaries from Blue Sky and pre-Spiderverse Sony, that would likely be viewed in a better light if it didn't spawn such a big franchise), moreso that Megamind is just that good.
although to be fair the only live action character I can think of off the top of my head who’d actually qualify would be Ignacio