Depends on the matchup and whether you're playing singles or doubles. It is also somewhat player dependent.
Against characters that are easy to tech chase with dthrow (Wario, Olimar, Meta Knight, Diddy Kong, Pikachu in the upper tiers alone,) or against a character we can chain grab release (Falco, Sheik because pummels refresh moves too,) you can abuse uptilt because a good dthrow chase or chaingrab will refresh it a lot. If your opponent gets hit with grenades often, you can abuse uptilt as well, although I don't think this should be relied on.
In doubles this doesn't apply so much because you have a partner that can kill your opponents too and you have other options like sticky c4 and team combos to do the job, so it's not a bad idea to just ***** it out for the range and good damage output imo
It's important to fully understand how the stale move queue works when you work out your gameplan for snake