trix for landing skillshots in lane
1. kill a low hp minion and shoot your skillshot through it right as he dies.
2. hit them when they last hit (LOL)
3. sit in a bush/outside fog of war so they can't see your casting animation
4. walk behind the creep line and shoot into them (only if ur stronger)
I'm personally a fan of conditioning your opponent to expect one thing and then reacting accordingly when it matters (when you can get a kill), eg.:
1. To harass, you approach the creepline and throw out a skillshot (maybe at the same angle every time) then immediately back up and continue to last-hit. Most likely your opponent reacts (by backing up) every time you approach
2. When you want that kill, approach but don't do anything (as if you can't get a clear shot) and start backing up
3.
As soon as your opponent turns around to come back to the creepline (because they don't expect anything to happen) you instantly turn back around and catch them offguard — if you're really confident you can do fancy stuff like flashing forward to close that gap instantly for a better shot, and then finishing them off with a combo/jungler gank
I use some variation of this to get tons of kills with the skillshot champs that I play (aka Lux) and it can really get into your opponent's head. It doesn't always work — for instance if your opponent is smart and knows your killing potential at any given point (and plays super safe) or if they're really dumb and you don't need anything beyond step 1.
It's all about trying to gauge your opponent's skill level and seeing what you can and can't get away with