Considering that the Amico's main selling point is that it only allows E and E10+ games, Earthworm Jim is a weird choice for a "killer app" as, while not exactly on the level of Conker or even Gex, Jim was known for innuendoes, gross-out, and having scuffles with Nintendo's censors - and his creator is somewhat notorious for opposing quote-unquote "SJW censorship".
Regardless, I can't help but feel like if we got a Mother echo it would be Ninten, and that would kinda mess his character up since he's not supposed to be able to use any offensive PSI techniques...