I hope we get some cool games this time around at Nintendo's E3. With the exception of the Galaxy 2 reveal (which I thought was an odd business choice at the time) and Other M (and I'm not a huge Metroid Fan at all), there wasn't a whole lot of titles I just went "wow" with. Course, that was a good distraction while I was bagon breeding....
I got a feeling we'll be seeing new Zelda and 3DS in particular, but I'm sure we'll get to see what the heck they have planned for the vitality sensor they revealed, More other M, and then a bunch a tittles for DSiWare (as they have to compete with apple for that market now). We might get some new images for Black and White (though I highly highly doubt it. Then again, we got Reshi and Zeki through the NOA adds and it seems like it's the 3DS's most developed game at this point), and a bunch of rumored games will be confirmed. Then Miamoto will come on stage at the last minute for the reveal of which series they plan to revive on Wii and/or DS. That or they will reveal the Wii See (so that they can compete with the new motion sensor market) or some other new accessory.
Usual offers are usual.