Again, I'm betting another major #1 issue will do it, if at all. Maybe Todd's Spider-Man, Jim's X-Men, or the Lee/Kirby X-Men. Or Fantastic Four. Who knows, maybe even Spawn #1 or TMNT#1 could do it. There's also Wonder-Woman, Flash, New Teen Titans, Web of Spider-Man(I think that was the Black Suit era book) and Giant Size X-Men. Can't see any 2000's titles doing that well outside of Walking Dead and MAYBE the first Ultimate Spider-Man #1. Then again Invincible is even more popular now thanks to its adaptation.
And that's not even getting into one of those three first record setters getting another pristine copy sold at a higher price a few years later.