Unown.
Here's a good one. The next game has all the same represented game series, but none of the same playable characters, meaning even Mario is absent. Imagine a roster of Kamek, Topi (Ice Climbers), Sylux, Viridi, Ghirahim, Eevee, Ashley, Rock Pikmin, Dracula, Akuma, etc..., or the next Smash game is a 2.5D fighter (like Tekken, but still has the iconic Smash mechanics) that only has twenty-five to thirty characters, with the original twelve being the last unlocked, and Mach Rider being part of the new starting roster of eight.