+85 attack Reverse Warlock Punch vs. +43 defense Mewtwo
Unfortunately, even with +43 defense, Mewtwo gets 1-hit KO'd by +85 attack Reverse Warlock Punch while on the stage center of an Omega form stage.
I have been experimenting how defense boosts can influence a fighter's survivability against one of the most powerful attacks in the game, and it seems that having a +43 defense can help avoid 1-hit KOs from +85 attack Reverse Warlock Punch, but ONLY for fighters with weight values set at 75 or better; those who are lighter than Mr. Game & Watch are still vulnerable to 1-hit KOs, which is very unfortunate for Mewtwo.
Now, just know that when I say 1-hit KO, I mean getting KO'd while your current damage is at 0%.