As long as the meme doesn't get exhausted like it did with Villager in Smash 4, then by all means have your fun. A few "deadly/evil Isabelle" memes won't hurt.
Now that being said, as someone who legitimately hates the "Ron the Death Eater" trope, I really don't want to see her get that treatment too much. I'd much rather her be subjected to that trope through memes than through over the top, edgy horror fanfics, though.
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On an unrelated note, I haven't been keeping up with speculation lately. What are some picks for the remaining four DLC characters people around here are feeling to be likely?