He absolutely can. I can think of at least 4 scenarios they can take with the character.
1. It could be a more internal endeavor where we actually see Connors reaction to events along with the Lizard's and the conflicts that come with his transformations.
2. There could be a follow-up to the idea I mentioned earlier where a storyline brought up that it might all be Curt Connors all along and he takes his anger out on his former unit and developing the Lizard-side's intelligence.
3. A What If scenario where Curt has remained in the Raft for decades and has permanently merged the two (a la Professor Hulk) which resulted in a bizarre middle personality that is curious but also cunning. It could be from the perspective from SHIELD agents who agree to work with this tumultuous creature who uses both of his intelligence and strength for their purposes (though he has agendas of his own).
4. Just a simple spin-off of the current Nick Spencer run where he's basically a good guy...