What I hope for is that if they do Palutena's Guidance for every character now, which means re-recording, when Palutena comes around to Medusa, I hope it's something like this.
Pit: It... can't be!
Palutena: Yes, I'm afraid it's none other than Medusa herself.
Medusa: Aw, you sound like my presence is unwanted here.
Pit: I never got the chance to thank you for helping us defeat Hades...
Medusa: I didn't do it for you guys! I only did it because I grew tired of Hades constantly reviving me for his amusement. Did you two ever wonder how I came back at the end?
Pit: Uh...
Medusa: It's a long story, and I'm not in the mood to speed things up, so let's just say every time Hades brought me back, I was used as a guinea pig for whatever scheme he had planning. Did you ever wonder WHY the Chaos Kin was so powerful?
Palutena: I do not want to think about that thing ever again.
Medusa: Too bad.
Palutena: But... with Hades gone, how are you even here?
Medusa: I'll tell you what I told you before our last battle. I don't know, and as usual, I don't care. Now, if you two are just going to cackle like hens, I'm just going to finish you both off.
Pit: Wait!
Medusa: What?!
Pit: I always wondered... what's the other side like? Is it scary?
Medusa: It's difficult to explain, but all you need to know was that I preferred it over Hades.
Palutena: Pit, Medusa may not be as huge as before. But, she's still a dangerous opponent. It's almost as if she's copying everything I can do, and putting an evil twist on my attacks. Granted, they are nowhere near as cool as my own.
Medusa: When I fight, I'm not going for style points. Even a vain goddess such as yourself would understand that!
Pit: So, it's almost like I'm fighting a mirror image of you, Palutena.
Medusa: I'm NOT a mirror image of Palutena! I am my own being, you worm!
Palutena: Technically, you are...
Medusa: Grr...
Pit: Anything else?
Palutena: Watch out for her Final Smash! You do not want to be anywhere near her when that happens.
Pit: Got it.
Medusa: I've waited 31 years for this moment. I will savor destroying you both.