I hope you are right Psycho. I can wait another 10 years to play as Isaac in Smash Bros. Geno... can't wait. Isaac can always get in because he's a 1st party character, and he's essentially Golden Sun's Marth. If the series continues and he remains important to it, sooner or later, Isaac is gonna be playable.
The fact this came from the horse's mouth... well... it may be a mind game. I got a feeling this may not mean 2 out of 3 playable, but 2 out of 3 are in the game. Because think about it: Why would Sakurai reveal that 2 out of 3 of those characters are playable=??? I mean, if Geno and Mega Man are in, 100% they are playable. But Isaac was in Brawl, and he was an Assist Trophy character.
So, what I think this means, assuming this is real, is that either Geno or Mega Man are playable. Then, the one of the two of them that aren't playable and Isaac may be playable. If none of those two are, then Isaac is an assist trophy character (again) or just a trophy (instead of also a trophy), boss, or sticker or something.
Edit: Furthering on about this "mind games," this is perfect hype. Sakurai probably did this on purpose if it's real. It automatically creates hype, and will make Smash the focus of E3! EXPECT NEWS!!!!