My first attempt at a moveset for anyone, so be gentle. D:
A - Sword jab.
A+A - Sword jab + slash.
A+A+A - Sword jab + slash + uppercut.
Dash+A - Cleave (Isaac runs and swings his sword downward).
A+f tilt - Strong sword slash.
A+u tilt - Upward thrust (Think Marth/Roy's smash^ except weaker...and no fire...).
A+d tilt - Sword swipe (He swipes the ground, tripping his opponent).
Nair - Sex kick.
Fair - Skull splitter - Looks like DK's fair (arms out, legs spread), except he uses his sword obviously. Smashes foes downward like Mario's fair.
Dair - Planet Driver - Similar to Link's dair except you can't bounce off them, Isaac's sword glows redish.
Uair - Upward thrust - again, like Link's uair.
Bair - Blind swipe - Isaac swipes behind him.
Fsmash - Force - Isaac pushes his opponent away with a psyenergy blast.
Dsmash - Quake Sphere - Isaac motions at the ground and a brown sphere is shown, after a few seconds it shoots a beam straight up, anyone caught in this gets carried upwards.
Usmash - Wild Growth - Send the foe upward with plants.
-Note- Isaac also has the ability to 'Hover', just like Peach. When he does this he is covered in a light blue aura.
Grab+A - Rockfall - Holds the foe with one hand and with the other summons stones on him/her.
Grab+Forward - Push - A giant hand pushes the foe away.
Grab+Backward - Rockslide - Isaac throws the foe backwards and summons stones to fall on the foe.
Grab+Down - Stone Spire - Isaac throws the foe to the ground and summons stone spires to dig into them.
Grab+Up - Venus uppercut - With the power of the earth emitting from his sword (so think rocks/dirt) Isaac sends the foe upward with an uppercut.
B - Cure - The longer you hold it the more damage you heal, has start up and ending lag. Recovers 1% every 2 seconds.
^B - Teleport - Using the Teleport Lapis Isaac teleports, a little bit shorter then Zelda's ^B. You control it just as you did Sheik's ^B.
vB - Mother Gaia - Isaac puts his hands up and a small area around him shakes and rocks rise up.
>B - Saber Dance - Isaac summons 3 spinning sabers to attack his enemies, you have control over these simalir to Link's boomerang, if they are reasonably close to the foe they will attack. (He should get a projectile, right?)
Final Smash ideas:
1. Megiddo (Isaac would of course be weilding the Sol Blade) Isaac jumps in the air as a huge fire-engulfed meteor falls near him, he strikes it downward onto the battlefield, if characters are hit with it they get either alot of damage OR knocked back alot, maybe both, it is a FS...
2. Judgement - Isaac summons the god of judgement,
http://youtube.com/watch?v=VMFb4Yr-bpE <- That dude. He appears in the background and causes the whole stage to start shaking uncontrollably, everytime a foe hits the ground they get sent right back up and take damage (think like when fire or acid hits you at Metroid levels), so Kirby and Peach can avoid this well.
3. Odyssey -
http://youtube.com/watch?v=PfBlwIiirW4 <-- Exactly that, works just like Link's FS.
Taunt 1 - Isaac floats in place, holding the Teleport Lapis in his hand, he is covered in a light blue aura.
Taunt 2 - A Venus Djiin lands on Isaac's head, he laughs it flies away.
Taunt 3 - A serious fighting stance, Isaac holds his sword outwards.
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I tried to fit as many actual attacks from the game as I could. Well?