I want to say that his regeneration is constantly fighting off increased aging (i.e. he is constantly 500 years old but his cells snap back in line), but with the trailer showing Claire being shot without her powers during the next episode and not being affected by any other previous injury, it falls flat.the "age catching up" to you doesn't make "scientific" sense either, assuming your non-aging stems from cellular regeneration
So yeah, I believe it's a little plot hole. But then again, it is a show about superheroes
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