I may have mentioned this before, but my dream game idea in general is a beat-em-up/fighter hybrid. Basically if there was a fighting game sub-genre that had somehow evolved from Double Dragon's VS mode rather than the likes of Yie-Ar Kung-Fu going onto Street Fighter or the Outfoxies begat Smash or Power Stone into regular 3D arena fighters we see today. Real Bout Fatal Fury's side-stepping also shows some of what it might be like. As far as I've seen, this is not a common enough fighting game sub-genre.
I think you'd also have to make it a bit simple in controls to make it appeal to most, similar to Smash, but on paper, I dunno how to make that look different, or what necessary changes may need to be done to accommodate differing movement options. License-wise, very natural ones could be a Battletoads or Battletoads VS Double Dragon or Ninja Turtles game, or maybe even a Simpsons one. Original characters/setting/story would also work very well, especially if they're colorful, varied, odd, but also easy enough to read.
I think you'd also have to make it a bit simple in controls to make it appeal to most, similar to Smash, but on paper, I dunno how to make that look different, or what necessary changes may need to be done to accommodate differing movement options. License-wise, very natural ones could be a Battletoads or Battletoads VS Double Dragon or Ninja Turtles game, or maybe even a Simpsons one. Original characters/setting/story would also work very well, especially if they're colorful, varied, odd, but also easy enough to read.