The lack of Lara Croft, Spyro and Crash really hurt PSASBR. Also having Don'te instead of Dante. I think if they tried again and kept the roster initially smaller but with decent "star power", they'd do well. Basically less reliance on guys like Big Daddy or Fat Princess who don't exactly scream "Playstation Legacy". Isaac from Dead Space is cool, but I don't think he's synonymous with the PS systems. And if you're gonna add multiple characters from a series someone more memorable than GoW's version of Zeus would be ideal.
PS1 Era - Crash, Lara, Spyro, Dart, Sir Dan, Parappa, Sweet Tooth, Heihachi, Jill Valentine
PS2 Era - Ratchet, Sly, Jak, Kratos, Dante, Raiden
PS3 Era - Nathan Drake, Kat, Joel/Ellie(basically Ice Climbers), Cole
PS4 Era - Knack BAYBEEE, Beard Kratos