A friend or even an enemy would be nice.Would you all want Isaac to bring along a friend??
Garet-I don't think he would be that interesting, especially compared to the other choices. He doesn't have any interesting psynergy, and there are enough fire moves in SSB already. Ike already has the fire-enhanced slow sword user angle covered. Certainly, it would be interesting to see a moveset based around fire itself (as opposed to movesets with fiery effects, like Roy or Falcon), and he could be an axe user, but I don't think it's worth it.
Ivan-He and Sheba would both be rather similar. If one of them got in, I think that Sheba would get the edge because she has a much cooler final smash possibilty (Catastrophe).
Mia-There's a good variety of possible water and ice moves that she could use, not to mention possible white-magic-esque moves too. She's a healer who uses a staff, so her physical attacks would be unique, too. She's also an interesting and important character in her own right. She could have a great moveset.
Felix-He would end up as a slower, more powerful clone of Isaac with a few different moves. I'd rather have a unique character instead, but if it was clone or nothing, I'd take clone.
Jenna-She could be interesting, but I don't think she would be interesting enough. She could use a short sword or staff, and she could use fire-based psynergy for a variety of attacks, but unless her moveset fully utilizes fire in non-derivative way, I don't think that she would end up being very unique or interesting.
Sheba-Catastrophe would be an awesome final smash, and it would make a great counterpart to Isaac's Judgment. Very few characters in SSB make much use out of wind or lightning. She could have some very neat wind-based evasive moves or attacks, along with lightning-enhanced close-range moves. She could easily have a fun, unique moveset.
Piers-Psynergy-wise, ice and water would make for some very unique moves. Diamond Berg anyone? As for physical moves, he would be a slow sword or axe user. Making him a sword user would be dull, but how neat would an axe-wielding ice-and-water adept be? He's also very important to the story. But personally, I would prefer Alex over him.
Saturos-He falls into the same category as Garet and Jenna. I don't think that any of them have a good amount of interesting psynergy, and Brawl hardly needs more fire.
Menardi-She has a scythe. That's awesome. Unfortunately, she is slightly less important than Saturos (e.g. players face Saturos alone once, then the two together.). She would be similar to Karst, and I think Karst would get the edge over her since Karst was slightly more important than Agatio in TLA, whereas Menardi was slightly less important than Saturos in GS1.
Agatio-He's a fire user with slow but strong punches. Basically, he's a Falcon/Ganondorf clone who can cast spells. That's not very interesting. He's also not that important to the story, so I don't think he has a shot anyway.
Karst-A scythe user would be very interesting and very unique, even if she is a fire adept. I would hope that she would get a good balance between scythe attacks and fire-based psynergy, and that all of her fire moves weren't simply making the scythe flaming. She isn't the most important character in the series, but I think that she has a better shot than Menardi or Agatio, and is tied with Saturos, as far as antagonists go.
Alex-He would be awesome. He could have a great variety of ice and water attacks. He also seems to carry around a dagger, so whether he went weaponless or used a dagger, he could have unique physical attacks. He would primarily rely on water or ice though, which would be very fun. He's also important to the story in both games, and especially in the ending, so he's a deserving character.
Of those possibilities, I would prefer Mia, Sheba, or Alex, or maybe Karst. I want Mia the most.