Well which RE protagonist would they do? Who knows. ; )
I FEEL like they could do Leon no problem. Jill if they wanted more female characters.
Wesker if they wanted more villains (Mind you we have 5 villain newcomers (dear god that's based))
Chris... idk, RE fans and/or followers what do y'all think?
Dimitrescu may not actually be off the table imo, she can be shrunken down like Ridley, also minus Wendy, we have 0 female villains.
West imo can't happen cuz we can't even see his face.
Claire Redfield, too I guess?
Well I already talked about it but I feel it would be either Jill, Chris or Leon.
It depends in how they approach it because each character has different positive things to their favor.
- Chris seems to be the one Capcom likes the most, if the quantity of appearances in main games is anything to go by. He has appeared in RE1, Resident Evil: Code Veronica X, Resident Evil 5, 6, 7 and 8. Plus he is the driving factor that leads Claire to Raccoon City in RE2, and he's also mentioned in RE3 where Jill, among other things, wants to find him. So even when he isn't around he usually is mentioned. He's also playable in RE Revelations.
- Jill is probably one of the most iconic female characters, at least from the PS1 era. Both her classic design and the RE3 design are quite recognizable, and she was in the original game, just as Chris. Resident Evil 3 is a beloved game among fans and she's the protagonist of the game. The thing "against" her is that she hasn't been playable in a numeric entry since ****ing Resident Evil 3, and if we talk about the whole series, her last playable appearance was Resident Evil Revelations which came out on 3DS.
- Leon is, based on my experience, probably the most popular character in the series. Or at least, tied with Jill for that spot. If we talk about numeric entries he has a more consistent track record than Jill. He debuted in RE2 where he shared the playable role with Claire, so he isn't from the original game, but RE2 is loved as much as the first game if not even more. Then Resident Evil 4, where he's the main character. This is probably the biggest thing he has going on for him, besides his popularity. RE4 was a breakout title for the series and a defining game for the industry, specifically for 3rd person action/shooter games. Series such as Dead Space were clearly inspired by RE4, for example. The game originally was a Gamecube exclusive as well (like the remake for the original RE1), until Capcom decided to publish it in other platforms because the average sales of the Gamecube. Then Leon also appeared in RE6 where he is one of the playable characters.
I personally feel it depends in how they approach it. If Sakurai and Nintendo just wanted a RE representative, and were very open to Capcom and their suggestions for who should they pick, I feel Capcom would push for Chris if his frequent appearances in the latest games is anything to go by. If Sakurai tries to go with a more crowd pleaser option, I think he would pick either Jill or Leon, because both are probably the most popular protagonist for non-RE fans, and that's probably thanks to their iconic designs (Chris has IMO a less "inspired" look) and playable roles in some of the most beloved and acclaimed games in the franchise.
I'd personally prefer Leon, who would definitely come with a his police uniform from RE2 and his iconic RE4 jacket outfit at the very least. But I'd be as happy with Jill or Chris as well.