Honestly, I wouldn't worry about that quote at all. Sakurai has a much bigger and experienced team this time. They aren't going to be cutting characters left and right.
Think about it. They would have to cut SOOOO many characters to stay around 39 characters. They already have 29 characters. Captain Falcon, Ness or Lucas, Meta Knight, Wario, at least one of Falco or Wolf...they're all basically guaranteed. That alone gives us a current roster of 34 if you only take one of Falco/Wolf and Ness/Lucas. The newcomers we have already have us at 40, and there is no sign that we're done just yet.
Expect at least a roster of 45.
One of my posts in this thread
#18038 , with assuming a max roster possibility of 42 I basically figured we would end up with having 5-6 characters cut, and be left with 2-3 new people to be announced from here on out to equal a total of 42. I don't think the cutting 5-6 characters is really so many. We already know some are not going to be returning for sure, and the fact is 5 characters were cut from melee to brawl (mewtwo, pichu, roy, young link, dr. mario).
To me, with the release only a few months away now, having 2-3 new characters in their pocket to announce sounds about right. I bet we will get one at E3 and the remaining two will be announced just before release, or be an in game surprise, possibly along with 1-2 unannounced returning veterans.
Again I will say, I would love to see a roster of 50 plus, but at this point having 21 or more unannounced characters doesn't seem right. I wish I could remember how they did it with brawl. I remember feeling like wolf and snake were in game surprises..