lolno.
The biggest antagonists in Nintendo are most-likely Bowser,Ganondorf,Ridley,and King Dedede (He's becoming more of an anti-hero now,actually)
1/4 right isn't going to cut it. King K. Rool is close,but he isn't the most recognized. Wolf is basically the
of StarFox. He's just a rival of sorts that first poses as a threat but later isn't as much of a threat and more of a nuisance. And Mewtwo...what? The villains of Pokemon are the organizations' leaders. Giovanni,Maxie,Ghetsis,those guys. Is the movie even canon? In-game,he's just a pokemon that you find,fight,and catch him. He just has a cruel backstory when it comes to the games. I hope I don't cause something from this.