If you expect even a fraction of that from a single Direct, you're going to leave disappointed.
Mario remasters are the most likely. Maybe a new Smash character, but we just got one announced not too long ago. It feels like yesterday to me. BOTW2 is possible, it seems like it's about time we hear about something again, but I don't know. Nintendo tends to keep Zelda mainline titles in the dark until they're close to release. Pokemon? They have their own presentations, but still could happen. Persona, I really don't know with that one. Atlus is opening up to more releases on the Switch, and Persona 4 Portable recently switched from being a PS Vita exclusive to coming on Steam as well. Hopefully we'll see some real Persona titles like that on the Switch.
The rest are where you really fall into things that are less likely to happen.
There is that FZero Twitter. I don't know what that means. Can there even be any confirmation it is even official? Is there something I'm not getting or is it likely to just be someone messing with FZero fans? Golden Sun? Look, I know it's a sensitive topic to all of us, and a new/remade Golden Sun popping up at any time is honestly far more likely than Isaac making it into SSBU at this point, but note that Isaac's chances of coming to Ultimate are abysmal. Metroid? Metroid Prime 4 got restarted like, what, a year ago? I doubt we'll be hearing about that this year. Another sidescrolling or spinoff is possible, I suppose, but I wouldn't count on it.