I remember hearing stories about anime producers removing characters if their voice actors died, for example.
Hideo Kojima personally retired MGS character Colonel Roy Campbell from the series after his Japanese voice actor died.
Not necessarily a Japanese thing, but some people do such things to honor those who passed away.
Yeah, Bill and Reggie could still do the American ones, same for Shibata in Europe. But what about Japan? Will the eventual new president want to continue doing such things?
There are questions that need to be answered in regards to the future of the Nintendo Directs.
Anyway, that Isaac looks a hell lot like a photoshopped Roy.