Tom Nook (Your boss in the first games, sells you your house, main ''goal" of the games) and Isabelle (guide to the mayor role, I'm not sure what her role in Happy Home Designer is as I haven't played it yet, but it seems fairly importantly) but what I'm saying is both function in different important ways for Animal Crossing.
As much as the Wario Ware characters are colorful and vibrant? And yes even cool in most cases.
None of them have gameplay functions that are vital to the series. Honestly, the mini games are the stars of those to the point even Wario seems second fiddle in it, which is why I'm always surprised Wario Ware is his default spin-off in Smash.