If you were just coming into this thread to disagree with Renth, then you're in the wrong place. If I assume correctly, this thread isn't an argument or a discussion with opposing sides... its a thread where we can all talk about the experiences or questions we've had that have seriously altered our lives or at least made us think deeply about them.
That said, I don't know why Mic was trying to be sarcastic. I do know that Cs_Nexus was on topic and on the right trail by saying that these sort of questions are a delicate balance. They're important questions to ask yourself, but if you do get too caught up in them, they can have serious repercussions on your psyche if you convince yourself that life is meaningless.
I've come to decide that while yes, humans are so insignificant when compared to the vast, dark literally emptiness that is the universe, that doesn't mean that our lives are insignificant at all. We are humans, and everything we know is from our perspective; therefore, everything we experience is important because it is the only thing we are able to define as "life." By interacting with lives that are on the same level of ours, we can influence them, love them, cherish them, hate them, share experiences with them, and spend time with them. Thats all we have really, is time. By making the most of our time by doing what we want to do (sharing experiences with those we love, doing what makes us happy, or pursuing our careers, life dreams, or goals), we make our lives meaningful.
Sure, in the end, we die. The fear that none of us know what will happen when we die is slightly baseless, and it should never prevent us from living how we want to live and accomplishing what we want to accomplish.
@Renth: I believe I know what you're talking about when you say that thoughts or discussions like these have really made you make changes to yourself. These thoughts of mine usually come with I'm depressed, when I've suffered a loss, or when I simply feel empty. After deep contemplation, I usually decide that everything is in my own hands and I make various changes in my life that can help me be happier, whether it be to end or re-establish a relationship with someone or it be to start working out or stop sleeping in.
These discussions are important. ^^