I vote for Mario.
Also... Mewtwo and Geno over the combined awesomeness of Megaman and Ganondorf? WTF people.
QFT, all of it. Megaman is the original powere stealer (Kirby is such a f***ing poser!
), and Ganondorf is sheer evil. Mewtwo isn't near as evil as Ganondorf. Well, I guess two movies makes you win, lol! XD
Issac can use the element Earth. Mario once went to the Moon. And Mars. And the Galaxy. All of the Galaxies. If they fought there, Issac would die, instantly.
Mario can use fireballs. Mario can turn into a racoon. Mario can turn into a statue. Mario can turn into a frog. Mario can fly with his cap. Mario can fly with his "powers". Mario can turn invisible. Mario can turn into invincible metal form of himself. Mario can shoot a giant fireball. Mario can wear a shoe. A giant shoe. He can turn into paper. He can fold. He can turn into a sailboat. He can breath in space. He can turn into a (paper) airplane. He has a water jet pack. He shoots himself out of cannons. He flys in space. He rides on dinosaurs, and other horrible, huge, and wierd creatures/things. He saves princess and damsels in distress day and night. He is a world-class sportsmen in every sports and other events and gaming genres. Spin-offs Basketball. Football. Soccer. Dancing. Tennis. Golf. Baseball. Parties. RPG games. Fighting games. Boxing. Bowling. More Baseball. More Tennis. More Golf. (thank you, Wii Sports). Mario IS GAMING. He's sold 200 million units. Golden Sun would be lucky to sell 2 million. Issace vs. Mario would be a slaughter house.
Mario wins.
End of story.
Get over it!