The most important thing from an academic viewpoint. ACTUALLY READ YOUR TEXT BOOKS AND REVIEW WHAT YOU LEARNED AS YOU GO. College is very autonomous and independent; you are responsible for keeping yourself ready for midterms, final exams, etc, it's very easy to fall behind.
I went through HS and the whole entire time I never once read any of my textbooks, I just did the homework, assignments, and tests and managed to get above a 4.0 (because of AP and honors classes). But College definitely is a whole 'nother level. I found out fast I could not skate through as easily as I had in High School, not even a fraction as difficult as College ended up being. Do not cram, do not procrastinate, and DO NOT BE THAT GUY THAT DOESN'T ACTUALLY DO HIS PART OF A GROUP PROJECT. Also don't be that guy that copies others homework. You are there to prepare for a career, take it seriously and you will remember a lot after you graduate, take advantage of hands on lab work, internships or assistant work related to your interests ASAP. You have to be proactive in college to make your degree valid in the real world (that and you wouldn't want all that money to be wasted).
From a social standpoint, if you want to get the most out of it, live near or on campus with roommates who are like minded. Say yes to any and all positive social opportunities, do a lot of study groups, get involved in organizations or clubs. College is where it's finally time to be yourself and others will gravitate to that, you will make lifelong friends and make sure you get a lot of healthy relationship experience. What I mean by that is don't be afraid anymore if you ever were. Ask someone out if you like them, tell them at the very least, just be confident and be yourself.