If there was any high tier matchup that I'd say would be easier for Yoshi than a spacie it would be Ice Climbers. Yoshi's Egg Lay (Neutral B) is one of the best tools in the game for separating Popo and Nana since it's ranged, can't be shielded, and leaves one of the climbers helpless for a short time. On top of that, Yoshi also has D-tilt and D-smash for separating them and F-air for killing Nana when she's offstage. If Yoshi jumps offstage at a low percent to kill Nana he doesn't have to worry about getting gimped from Popo since his super armor will muscle through whatever is thrown at him.