I'd call this one in Snakes favor. In addition to having RPG's, Grenades, MINES, C4, and all of his numerous gadgets that also exist IRL, he has the tactical advantage as well. Being human he would be able to easily identify his options.
While there is some "OMGWTFGORRILA" involved, if DK were to charge immediately (which he would have to, assuming he has no access to projectiles, are we giving him the coconut gun?), Snake can still react by hucking a C4 or what have you. Now, if DK manages to get in close, Snake is pretty much screwed. Nobody is happy when you're brutally beaten to death by a Simian.
I'll call this one for Snake, I think.